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💊 How Tramadol Works (Step-by-Step)
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What It Is
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Tramadol is a centrally acting pain reliever (analgesic).
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It’s considered a weak opioid, used for moderate to moderately severe pain.
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Dual-Action Mechanism
Tramadol works in two main ways:a. Opioid Receptor Activation
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Tramadol binds to mu-opioid receptors in the brain and spinal cord.
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This helps block pain signals and change how the brain perceives pain.
b. Neurotransmitter Reuptake Inhibition
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Tramadol also inhibits the reuptake of serotonin and norepinephrine — two important brain chemicals involved in mood and pain regulation.
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This increases their levels in the brain, which helps enhance pain relief.
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